Sexual Health

Lupron · GnRH Long-Acting Agonist

A long-acting GnRH agonist, FDA-approved for prostate cancer, endometriosis, and precocious puberty. Paradoxically suppresses sex hormones through pituitary desensitization.

GnRH Agonist / Hormone SuppressionFDA Approved (Lupron)

Decapeptyl · GnRH Long-Acting Agonist

A long-acting GnRH agonist, FDA-approved for prostate cancer via androgen deprivation. Used off-label in some hormone protocols.

GnRH Agonist / OncologyFDA Approved: Trelstar (triptorelin pamoate) for advanced prostate cancer; Triptodur (triptorelin depot) for central precocious puberty in children 2+

Bremelanotide · Melanocortin Agonist (Vyleesi)

The only FDA-approved peptide for sexual dysfunction, and the one most used off-label.

Sexual DysfunctionFDA approved June 2019 as Vyleesi (bremelanotide injection, 1.75 mg subcutaneous) for acquired, generalized HSDD in premenopausal women; off-label injectable PT-141 for male ED or general libido is unapproved, and compounded PT-141 (including nasal spray) is not FDA-approved.

Synthetic GnRH

Gonadorelin is the natural GnRH decapeptide. It was formerly FDA-approved as Factrel for pituitary diagnostic testing and as Lutrepulse for pulsatile ovulation induction, both now discontinued in the US, so it is available only through compounding. Men's TRT clinics now use it off-label, injecting it to keep the testes stimulated during testosterone therapy, an unapproved application that the clinics themselves acknowledge has a limited controlled-trial base.

GnRH / ReproductiveFormerly FDA-approved as Factrel (diagnostic) and Lutrepulse (pulsatile ovulation-induction therapy); both discontinued for commercial reasons; no FDA-approved product currently marketed in the US, available only via 503A/503B compounding by prescription.

Nine-AA Hypothalamic Neuropeptide

The first peptide ever synthesized, a Nobel Prize, 1955. Now an intranasal favorite.

Social Bonding / NeuromodulatorIV oxytocin (Pitocin) FDA-approved for labor induction/stimulation and postpartum bleeding; intranasal oxytocin NOT approved, compounded off-label

KISS1 Peptide / Metastin

The master switch for puberty and reproductive hormones. Named after Hershey Kisses.

Reproductive / Sexual HealthNo FDA-approved kisspeptin product; investigational only, tested in early-phase and Phase 2 academic trials (Imperial College London) for IVF oocyte-maturation triggering and hypoactive sexual desire disorder

MT-II / Cyclic MSH Analog

The "Barbie drug." Tanning and libido. Multiple FDA warnings. Huge gray market.

Tanning / Sexual HealthNot approved; FDA warning letter to Melanocorp (2007) and later felony conviction plus debarment of a supplier (Manookian, 2016)

PNX-14 Anorexigenic Neuropeptide

A hypothalamic neuropeptide first identified in 2013, cleaved from the SMIM20 precursor and signaling through the orphan receptor GPR173. In animal and cell studies it is associated with reduced anxiety-like behavior, positive regulation of the reproductive axis, and metabolic and anti-inflammatory signaling. Human data are limited to observational associations of circulating phoenixin-14 with conditions such as PCOS, obesity and type 2 diabetes, with no human intervention trials.

Neuropeptide / ReproductiveNot FDA approved; no marketing application. Human work to date is observational measurement of endogenous levels, not administration.

Lys-Glu-Asp-Pro Prostate Bioregulator

Prostamax is the synthetic Khavinson tetrapeptide KEDP (Lys-Glu-Asp-Pro), the defined-sequence successor to the Russian bovine prostate extract Prostatilen/Vitaprost; it is associated in preclinical Russian rat and cell-culture models with reduced prostate inflammation and reparative signals, but it has no Western RCTs, no independent replication and no FDA or EMA approval.

Prostate BioregulatorNo FDA approval; not an FDA-approved drug and sold in the US only as a research chemical labeled not for human consumption. Not an EMA-approved medicine. (Separately, the related bovine extract Prostatilen/Vitaprost is registered as a medicine in Russia, not in the US or EU.)

Lys-Glu-Asp-Gly Gonadal Bioregulator

A Khavinson tetrapeptide targeting testicular gene expression and testosterone maintenance in aging men. Russian data only.

Gonadal BioregulatorNot approved by the FDA for any indication; not evaluated by any Western regulator; no ClinicalTrials.gov registration; sold in the United States only as a research chemical labeled not for human use