FMT · Whole-Microbiome Transfer
The most powerful microbiome intervention known. FDA-approved for recurrent C. difficile.
The Probiotic and Microbiome Library
Probiotics
Strains, brands and foods, and the gap between what a label claims and what the strain in it was actually tested for.
31 entries, ordered below with the best evidenced first.
What the evidence looks like across all 31 entries
Most of this library rests on human evidence.
| Grade | entries |
|---|---|
| 5Settled | 1 |
| 4Strong | 12 |
| 3Mixed | 14 |
| 2Thin | 4 |
| 1Untested | 0 |
13 entries rest on strong human evidence. 4 rest on little or none. How we grade evidence.
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Mass-Market B. infantis 35624 (P&G)
The mass-market home of the strongest IBS strain. Genuine evidence in a pharmacy product.
Probiotics' Best-Evidence Use Case
Preventing diarrhea caused by antibiotics is the strongest, best-evidenced use of probiotics, with specific strains clearly ahead.
Mass-Market LGG Brand (DSM-Firmenich)
A commodity product hiding the world most-studied strain. Excellent value-for-evidence.
Whole-Food Probiotic Sources
The Stanford study that beat fiber. Kefir, kimchi, sauerkraut, miso, natto, yogurt.
LGG · The Most-Studied Probiotic Strain
The single most studied probiotic strain on earth. The strain inside Culturelle.
Whole-Food Fermentable Fiber Sources
Chicory, garlic, onion, green banana, oats, legumes. Feed the bacteria you already have.
Fermentable Fibers That Feed the Microbiome
You cannot out-supplement a bad diet. Prebiotics feed the bacteria you already have.
CNCM I-745 · The Probiotic Yeast
A yeast, not a bacterium, so antibiotics cannot kill it. Take them together.
Butyrate, Propionate & Acetate
The real output of the microbiome. Butyrate fuels your colon and quiets inflammation.
Why "Probiotics" Is the Wrong Question
The most important and most ignored fact in probiotics: effects are strain-specific and disease-specific, not a general "probiotic" property.
Do Probiotics Even Stick Around?
Most probiotics do not permanently colonize the gut, they pass through, and that reframes how they could possibly work.
The High-Potency Multi-Strain With Real Evidence
A high-dose 8-strain probiotic with genuine evidence for pouchitis, and a cautionary tale about formula identity and branding.
Next-Generation Mucin-Degrading Probiotic
A gut-lining bacterium tied to metabolic health, leanness, and immunotherapy response.
Bifidobacterium · The IBS Strain (Align)
The single strain with the strongest IBS evidence. The strain inside Align.
Spore Strain · MTCC 5856 / LactoSpore
The most-studied spore probiotic. IBS, muscle recovery, and excellent survivability.
Refrigeration & Probiotic Viability
Refrigeration signals formulation quality, not viability at the moment you swallow it.
The Probiotic That Is a "Bad" Bacterium
A century-old probiotic strain of E. coli, evidence-backed for maintaining ulcerative colitis remission, as effective as standard mesalamine in trials.
Microbiome-Nervous System Communication
The microbiome talks to the brain. 90% of serotonin is made in the gut.
Fermented Milk · Highest Natural CFU
30+ strains of bacteria and yeasts in one cup. The richest naturally probiotic food.
The Strain Behind a Yogurt Craze
A well-studied strain with real evidence for infant colic, recently the center of a viral "L. reuteri yogurt" longevity craze.
Fermented Soybean · B. subtilis + K2
Fermented with B. subtilis natto, and the single richest dietary source of vitamin K2.
Beneficial Bacterial Metabolites & Components
The benefit without the live bacteria. Butyrate, urolithin A, equol, heat-killed cells.
Daily Synbiotic · 24-Strain Capsule
The most scientifically marketed probiotic in the DTC space. Every strain individually cited.
Bacillus Endospore-Forming Bacteria
Heat- and acid-proof bacteria that survive where Lactobacillus dies. The survivability category.
Paired Probiotic + Prebiotic Formulations
Probiotic plus the prebiotic that feeds it. Most "synbiotics" are not true synbiotics.
Lactobacillus & Bifidobacterium
The dominant category, decades of evidence, native to the human gut, and fragile by nature.
Spore Strain · HU58 / DE111
A soil and natto bacterium that makes its own antibiotics to crowd out pathogens.
Mass-Value Multi-Strain (Perrigo-made)
Common strains, reasonable doses, low price. Often the same factories as branded products.
Premium Refrigerated Multi-Strain (Nestlé)
A respected natural brand under a controversial parent. High strain counts, refrigerated lines.
Spore-Based Probiotic · 4-Strain Bacillus
Spore-based survivability is the strongest argument against fragile Lactobacillus products.
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