1,3,7-Trimethylxanthine · The World's Most Consumed Stimulant
The world's most consumed psychoactive, with the cleanest performance evidence of any stimulant.
Supplements
Brain & Cognition
Focus, memory, neuroprotection
19 products. 4 rest on strong human evidence. Ordered with the best evidenced first.
19 products in Brain & Cognition
Creatine Monohydrate · The Phosphocreatine Buffer
The most-validated sports supplement, expanding into brain and longevity.
Cobalamin · Methyl, Cyano, Hydroxo, Adenosyl
Foundational, cohort-dependent, and the form debate is smaller than getting enough.
N-Acetylcysteine · Cysteine / Glutathione Precursor
Pharmaceutical-grade glutathione precursor that briefly disappeared from US supplement shelves, and came back.
Withania somnifera · Ayurvedic Rasayana
Most-researched adaptogen of the modern era, with the cortisol data to back it up.
Bacopa monnieri · Brahmi (Ayurvedic) · Water Hyssop
The Ayurvedic Medhya Rasayana with substantial modern cognitive RCT inheritance, slow-onset, real-effect.
Essential Nutrient · Acetylcholine Precursor
Almost everyone gets less than they need, and the prenatal data is real.
Curcumin / Curcuminoid Standardized Extract (Curcuma longa)
The substantial anti-inflammatory polyphenol, formulation matters substantially.
γ-Glutamylethylamide · The Green-Tea Amino Acid
The focus-without-jitters story, and the rare synergy claim that actually holds up.
Fish-Oil Polyunsaturated Fatty Acids
The classic case of observational positive, randomized null, at supplement doses.
Panax ginseng · Asian Ginseng · Korean Red Ginseng
The "all-healing" panacea root with two millennia of Korean tradition and substantial modern clinical evidence, and substantial adulteration concerns.
Apigenin / 4',5,7-Trihydroxyflavone (Parsley, Celery, Chamomile)
The dietary flavonoid with senolytic and sleep-modulating positioning.
Ginkgo biloba · The Living Fossil · EGb 761
Living fossil with two centuries of medical use, and two major modern trials that failed to prevent dementia.
Centella asiatica · Brahmi (Ayurvedic) · Indian Pennywort
The Ayurvedic cognitive herb confused with Bacopa, and a substantial European microcirculation tradition.
Ocimum sanctum · Tulsi · The Queen of Herbs
Three thousand years of Ayurvedic veneration meets modest modern stress evidence.
Hericium erinaceus · Functional Mushroom
A real mechanism, modest evidence, and a form-factor problem most consumers don't see.
Magnesium Bisglycinate Chelate
The reference form of magnesium, high absorption, easy on the gut.
Schisandra chinensis · Wu Wei Zi · The Five-Flavor Berry
The five-flavor berry with parallel Chinese hepatic and Soviet performance research traditions.
2-Aminoethanesulfonic Acid · The Ox-Bile Amino Acid
From ox bile to energy drinks to longevity science, and a real Japanese cardiology heritage in between.