Cholecalciferol · Fat-Soluble Hormone-Vitamin
The most-tested supplement on Earth, strongest in deficiency, modest in replete adults.
Supplements
Bone & Joints
Density, mobility, joint comfort
11 products. 2 rest on strong human evidence. Ordered with the best evidenced first.
11 products in Bone & Joints
Carbonate · Citrate · Macromineral
Dietary first, supplementation when there's a documented reason.
Boswellia serrata / Indian Frankincense Resin Extract
The 5-LOX inhibitor anti-inflammatory, distinct mechanism from NSAIDs.
Hydrolyzed Collagen · Type I, II, III · Bioactive Peptides
A massive market with a real branded-peptide story underneath the marketing.
Menaquinone-7 (MK-7) · Menaquinone-4 (MK-4)
Strong mechanism, maturing outcome evidence, and the form really does matter.
Conditionally Essential Trace Mineral
Conditionally essential, and most Western diets fall short of the dose range with benefit evidence.
Glucosamine Sulfate + Chondroitin Sulfate · Joint Building Blocks
The most-purchased joint supplement, with a famously divided evidence base.
Sodium Hyaluronate · Hyaluronan · The Water-Binding Polymer
The water-binding polymer that fills nearly every interstitial space, and a recent oral category with modest evidence.
Methylsulfonylmethane · Dimethyl Sulfone · Organic Sulfur Donor
A sulfur donor with modest evidence for joint comfort and exercise recovery.
Silicon Dioxide · From Horsetail (Equisetum arvense)
An ancient plant's silicon mineral content, modest evidence, mechanistically coherent.
Curcuma longa · Haridra · Curcuminoids
Four thousand years old, a real anti-inflammatory, and a formulation puzzle.