1,3,7-Trimethylxanthine · The World's Most Consumed Stimulant
The world's most consumed psychoactive, with the cleanest performance evidence of any stimulant.
Supplements
Energy & Performance
Mitochondria, stamina, athletic output
18 products. 5 rest on strong human evidence. Ordered with the best evidenced first.
18 products in Energy & Performance
Creatine Monohydrate · The Phosphocreatine Buffer
The most-validated sports supplement, expanding into brain and longevity.
Essential Mineral · Heme & Non-Heme Forms
Strongly beneficial in deficiency, genuinely harmful when replete.
Cobalamin · Methyl, Cyano, Hydroxo, Adenosyl
Foundational, cohort-dependent, and the form debate is smaller than getting enough.
β-Alanine · The Carnosine Precursor
The cleanest ergogenic for 1-4 minute maximal efforts, with a signature tingle.
α-Lipoic Acid · Thioctic Acid · The Universal Antioxidant
A German prescription drug for diabetic neuropathy, a US supplement for metabolic health.
Coenzyme Q10 · Ubidecarenone · Mitochondrial Electron Carrier
The mitochondrial cofactor with the cleanest heart-failure meta-analysis of any supplement.
L-Arginine · The Original NO Substrate
The original nitric oxide substrate, largely supplanted by L-citrulline in modern supplement protocols.
L-Citrulline · The Watermelon Amino Acid
The watermelon amino acid that delivers L-arginine's benefits without L-arginine's pharmacokinetic problem.
Panax ginseng · Asian Ginseng · Korean Red Ginseng
The "all-healing" panacea root with two millennia of Korean tradition and substantial modern clinical evidence, and substantial adulteration concerns.
Branched-Chain Amino Acids · Leucine, Isoleucine, Valine
A supplement category whose mechanism is real but whose use case has been substantially superseded by whole protein.
Cordyceps militaris · Sinensis · Tibetan Fungus
Two species, one tradition, fifteen hundred years, and a sustainability crisis.
Eleutherococcus senticosus · "Siberian Ginseng" · The Cold War Adaptogen
Cold War-era Soviet performance research repackaged as Siberian ginseng, and prohibited from that name in the EU since 2003.
L-Glutamine · The Most Abundant Plasma Amino Acid
A critical-care amino acid with consumer marketing that exceeds the supplement evidence.
Nicotinamide Mononucleotide · NAD+ Precursor
The flagship longevity supplement of the 2020s, and the most commercially conflicted.
Rhodiola rosea · Russian / Scandinavian Adaptogen
The non-Asian adaptogen. Modest, real, reliable.
Schisandra chinensis · Wu Wei Zi · The Five-Flavor Berry
The five-flavor berry with parallel Chinese hepatic and Soviet performance research traditions.
2-Aminoethanesulfonic Acid · The Ox-Bile Amino Acid
From ox bile to energy drinks to longevity science, and a real Japanese cardiology heritage in between.