1,3,7-Trimethylxanthine · The World's Most Consumed Stimulant
The world's most consumed psychoactive, with the cleanest performance evidence of any stimulant.
The Supplement Intelligence Library
Supplements
What is actually in the bottle, what the trials found, and who is paid to tell you otherwise.
74 products, ordered below with the best evidenced first.
What the evidence looks like across all 74 products
Most of this library rests on human evidence.
| Grade | products |
|---|---|
| 5Settled | 10 |
| 4Strong | 6 |
| 3Mixed | 23 |
| 2Thin | 31 |
| 1Untested | 4 |
16 products rest on strong human evidence. 35 rest on little or none. How we grade evidence.
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Creatine Monohydrate · The Phosphocreatine Buffer
The most-validated sports supplement, expanding into brain and longevity.
Folic Acid · 5-MTHF · Vitamin B9
Among the highest-evidence interventions in all of nutrition.
Essential Trace Mineral · Thyroid Critical
Iodized salt is one of public health's greatest wins. The pregnancy window is non-negotiable.
Essential Mineral · Heme & Non-Heme Forms
Strongly beneficial in deficiency, genuinely harmful when replete.
Essential Trace Mineral
Geography matters. The therapeutic window is real, narrow, and worth respecting.
Cobalamin · Methyl, Cyano, Hydroxo, Adenosyl
Foundational, cohort-dependent, and the form debate is smaller than getting enough.
Ascorbic Acid · Water-Soluble Antioxidant
The cleanest reference supplement, settled, modest, real.
Cholecalciferol · Fat-Soluble Hormone-Vitamin
The most-tested supplement on Earth, strongest in deficiency, modest in replete adults.
Alpha-Tocopherol · Mixed Tocopherols
The textbook observational-versus-randomized reversal.
β-Alanine · The Carnosine Precursor
The cleanest ergogenic for 1-4 minute maximal efforts, with a signature tingle.
Carbonate · Citrate · Macromineral
Dietary first, supplementation when there's a documented reason.
N-Acetyl-5-Methoxytryptamine · Pineal Hormone
A real hormone, sold like a supplement, dosed ten times higher than the physiology suggests.
N-Acetylcysteine · Cysteine / Glutathione Precursor
Pharmaceutical-grade glutathione precursor that briefly disappeared from US supplement shelves, and came back.
S. boulardii CNCM I-745 · The Probiotic Yeast
The probiotic yeast, antibiotic-resistant, heat-stable, and the cleanest C. diff evidence in the category.
Essential Trace Mineral
A real immune mineral with a narrow window, more is not better.
α-Lipoic Acid · Thioctic Acid · The Universal Antioxidant
A German prescription drug for diabetic neuropathy, a US supplement for metabolic health.
Withania somnifera · Ayurvedic Rasayana
Most-researched adaptogen of the modern era, with the cortisol data to back it up.
Bifidobacterium longum 35624 · The IBS Probiotic
The probiotic with the cleanest IBS evidence, and the marketing-vs-evidence story behind Align.
Bacopa monnieri · Brahmi (Ayurvedic) · Water Hyssop
The Ayurvedic Medhya Rasayana with substantial modern cognitive RCT inheritance, slow-onset, real-effect.
Berberine · Isoquinoline Alkaloid · "Nature's Ozempic" (Misleading) · AMPK Activator
Isoquinoline alkaloid · metformin-comparable HbA1c · "Nature's Ozempic" viral framing · substantial drug-supplement boundary.
B. animalis subsp. lactis BB-12 · The Most-Studied Bifidobacterium
The most-studied Bifidobacterium, and a reminder that "Bifidobacterium lactis" generically is not the same as BB-12.
Boswellia serrata / Indian Frankincense Resin Extract
The 5-LOX inhibitor anti-inflammatory, distinct mechanism from NSAIDs.
Cannabidiol · Phytocannabinoid · FDA-Approved Epidiolex Drug + Dietary Supplement
Phytocannabinoid · FDA-approved epilepsy drug · disputed supplement status · substantial M-05 regulatory whiplash.
Essential Nutrient · Acetylcholine Precursor
Almost everyone gets less than they need, and the prenatal data is real.
Hydrolyzed Collagen · Type I, II, III · Bioactive Peptides
A massive market with a real branded-peptide story underneath the marketing.
Coenzyme Q10 · Ubidecarenone · Mitochondrial Electron Carrier
The mitochondrial cofactor with the cleanest heart-failure meta-analysis of any supplement.
Curcumin / Curcuminoid Standardized Extract (Curcuma longa)
The substantial anti-inflammatory polyphenol, formulation matters substantially.
Grape Seed Extract · Vitis vinifera OPC · Endotelon Heritage
The cost-effective OPC alternative with wine industry sustainability and European pharmaceutical heritage.
L-Arginine · The Original NO Substrate
The original nitric oxide substrate, largely supplanted by L-citrulline in modern supplement protocols.
L-Citrulline · The Watermelon Amino Acid
The watermelon amino acid that delivers L-arginine's benefits without L-arginine's pharmacokinetic problem.
γ-Glutamylethylamide · The Green-Tea Amino Acid
The focus-without-jitters story, and the rare synergy claim that actually holds up.
Lactobacillus reuteri DSM 17938 · The Infant Colic Probiotic
The probiotic with the cleanest pediatric infant colic evidence, strain-specific, mother's milk origin.
LGG · ATCC 53103 · The Reference Probiotic Strain
The reference probiotic, and proof that the strain name actually matters.
Magnesium Citrate · Form-Factor Sibling
A two-for-one, magnesium supplementation when low-dose, GI relief when high.
Fish-Oil Polyunsaturated Fatty Acids
The classic case of observational positive, randomized null, at supplement doses.
Panax ginseng · Asian Ginseng · Korean Red Ginseng
The "all-healing" panacea root with two millennia of Korean tradition and substantial modern clinical evidence, and substantial adulteration concerns.
Trametes versicolor · PSK · Yun Zhi
A real approved cancer drug in Japan, sold as a supplement in the US.
Menaquinone-7 (MK-7) · Menaquinone-4 (MK-4)
Strong mechanism, maturing outcome evidence, and the form really does matter.
Single-Brand Foundational Daily Greens Powder
The original influencer-economy daily greens, and the consumer category it created.
A. muciniphila · The Mucin-Degrading Symbiont
Next-generation probiotic, the mucus-layer symbiont with metabolic-health emerging evidence.
Apigenin / 4',5,7-Trihydroxyflavone (Parsley, Celery, Chamomile)
The dietary flavonoid with senolytic and sleep-modulating positioning.
Branched-Chain Amino Acids · Leucine, Isoleucine, Valine
A supplement category whose mechanism is real but whose use case has been substantially superseded by whole protein.
Conditionally Essential Trace Mineral
Conditionally essential, and most Western diets fall short of the dose range with benefit evidence.
Cordyceps militaris · Sinensis · Tibetan Fungus
Two species, one tradition, fifteen hundred years, and a sustainability crisis.
Eleutherococcus senticosus · "Siberian Ginseng" · The Cold War Adaptogen
Cold War-era Soviet performance research repackaged as Siberian ginseng, and prohibited from that name in the EU since 2003.
Ginkgo biloba · The Living Fossil · EGb 761
Living fossil with two centuries of medical use, and two major modern trials that failed to prevent dementia.
Glucosamine Sulfate + Chondroitin Sulfate · Joint Building Blocks
The most-purchased joint supplement, with a famously divided evidence base.
Centella asiatica · Brahmi (Ayurvedic) · Indian Pennywort
The Ayurvedic cognitive herb confused with Bacopa, and a substantial European microcirculation tradition.
Ocimum sanctum · Tulsi · The Queen of Herbs
Three thousand years of Ayurvedic veneration meets modest modern stress evidence.
Sodium Hyaluronate · Hyaluronan · The Water-Binding Polymer
The water-binding polymer that fills nearly every interstitial space, and a recent oral category with modest evidence.
L-Glutamine · The Most Abundant Plasma Amino Acid
A critical-care amino acid with consumer marketing that exceeds the supplement evidence.
Hericium erinaceus · Functional Mushroom
A real mechanism, modest evidence, and a form-factor problem most consumers don't see.
Magnesium Bisglycinate Chelate
The reference form of magnesium, high absorption, easy on the gut.
Silybum marianum · Silymarin · St. Mary's Thistle
Two thousand years of liver-protective tradition, meeting modern bioavailability and clinical trial reality.
Methylsulfonylmethane · Dimethyl Sulfone · Organic Sulfur Donor
A sulfur donor with modest evidence for joint comfort and exercise recovery.
Nicotinamide Mononucleotide · NAD+ Precursor
The flagship longevity supplement of the 2020s, and the most commercially conflicted.
Pterostilbene · The Methylated Resveratrol with 80% Bioavailability
What resveratrol would be if pharmacology actually translated.
Pycnogenol · French Maritime Pine Bark Extract (Horphag)
The single-source branded OPC, premium-priced for substantial brand-specific clinical evidence inheritance.
Quercetin · The Flavonol Mast Cell Stabilizer
The natural antihistamine that works through a different mechanism than the pharmaceutical one.
Ganoderma lucidum · Lingzhi · "Spirit Mushroom"
A two-thousand-year traditional inheritance and a real modern mechanism.
Trans-Resveratrol · The Sirtuin Sirtris Story
The longevity headliner whose mechanism story was bigger than the clinical translation.
Rhodiola rosea · Russian / Scandinavian Adaptogen
The non-Asian adaptogen. Modest, real, reliable.
Schisandra chinensis · Wu Wei Zi · The Five-Flavor Berry
The five-flavor berry with parallel Chinese hepatic and Soviet performance research traditions.
Seed DS-01 Daily Synbiotic · 24-Strain Probiotic + Prebiotic Polyphenols
The science-positioning DTC probiotic synbiotic, substantial transparency, advisory framework, sustainability.
Silicon Dioxide · From Horsetail (Equisetum arvense)
An ancient plant's silicon mineral content, modest evidence, mechanistically coherent.
Spermidine / Polyamine (Wheat Germ, Soy, Aged Cheese)
The autophagy-inducing polyamine, substantial longevity research framework.
2-Aminoethanesulfonic Acid · The Ox-Bile Amino Acid
From ox bile to energy drinks to longevity science, and a real Japanese cardiology heritage in between.
Curcuma longa · Haridra · Curcuminoids
Four thousand years old, a real anti-inflammatory, and a formulation puzzle.
Valeriana officinalis · The Sleep Root
Two thousand years of sleep tradition, modest modern evidence, real GABA-A mechanism.
Bloom Greens & Superfoods · Mari Llewellyn · Nestlé Health Science
The viral TikTok answer to AG1, accessibly priced, flavored, mass-market retail.
Inonotus obliquus · Birch-Tree Fungus
The highest-ORAC mushroom, with a real oxalate-related kidney concern.
Huel Daily Greens · UK Plant-Based Multi-Ingredient Greens · 91 Ingredients
The European maximalist plant-based answer to AG1, 91 ingredients, mushroom-integrated.
Live It Up Daily Greens · Plant-Based Multi-Greens Powder
The focused-minimalist plant-based greens DTC alternative in the AG1 framework.
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